our services

Medicinal Chemistry

At Anugraha Lifescience, our Medicinal Chemistry Services are integral to the drug discovery process, focusing on designing and optimizing molecules to develop effective and safe therapeutics. We specialize in the Hit-to-Lead and Lead Optimization phases, employing a combination of structure-based and ligand-based approaches to enhance drug efficacy and minimize side effects.

Our Proven Medicinal Chemistry Workflow

  • Target Identification & Validation:
    Identifying and confirming disease-related targets to ensure therapeutic relevance.
  • Hit-to-Lead Optimization:
    Refining hits into leads with improved potency, selectivity, and safety.
  • Lead Optimization & Preclinical Development:
    Enhancing pharmacokinetics, toxicity profiles, and advancing to preclinical studies.
  • IND-Enabling Medicinal Chemistry Studies:
    Supporting IND submissions with regulatory-compliant chemistry packages.
  • Structure-Based & Ligand-Based Drug Design (SBDD & LBDD):
    Optimize protein-ligand interactions and enhance compound activity.
  • Chemical Synthesis & SAR Optimization:
    Iterative synthesis guided by SAR insights to improve drug-like properties.
  • Hit Identification & Lead Generation:
    High-throughput screening and focused validation to generate strong leads.
  • Combinatorial Chemistry:
    Efficient generation of compound libraries for broad exploration of chemical space.
  1. Expertise across diverse medicinal chemistry platforms.
  2. Integrated hit-to-lead and lead optimization workflows.
  3. Comprehensive library synthesis capabilities.
  4. Strict adherence to global quality standards.